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This paper constructs an index system for evaluating the efficiency of COVID-19 sporadic outbreak prevention and control from three dimensions (epidemic prevention and control, epidemic traceability, and epidemic background) and with nine sub-indicators (pidemic duration, confirmed cases, detection route, mobile population management policy, flow investigation and tracing, nucleic acid detection, etc.) This evaluation index system is used to calculate and evaluate the control of epidemic in all the 32 regions of Chian since June 1, 2020 to June 1, 2021. Results show that there were significant differences in the efficiency of epidemic prevention and control among these regions, that the intensity of prevention and control measures did not match the severity of the epidemic, and that the management policies for mobile populations across regions lacked a unified yet scientific basis. Based on these, certain epidemic prevention and control management optimization suggestions are presented.
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We define the concept and analyze the connotation of the post-pandemic era by reviewing the recent foreign research on social impacts, risk prevention and control, and emergency management in the post-pandemic era. The current state of foreign research in the post-pandemic era is outlined, and the progress of foreign research on social impacts like urban planning and travel patterns, as well as core issues like risk prevention and control and emergency management in the post-pandemic era is analyzed in detail. The characteristics and shortcomings of existing research are summarized and future research in the postpandemic era is also forecasted. COVID-19 has had a huge impact on how people socialize, travel, and work, as well as changing industry trends, technical advancements, and social governance. Uncertainty is the most significant risk feature of the post-pandemic era, and the coupling of numerous hazards poses a new set of challenges to emergency management practices.
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OBJECTIVES: Available data show that COVID-19 vaccines may be less effective in people living with HIV (PLWH) who are at increased risk for severe COVID-19. This meta-analysis aimed to compare the immunogenicity and efficacy of COVID-19 vaccines in PLWH with healthy individuals. METHODS: Pubmed/Medline, EMBASE, and the Cochrane Library were searched. Risk ratios of seroconversion were separately pooled using random-effects meta-analysis, and a systematic review without meta-analysis of SARS-CoV-2 antibody titer levels was performed after the first and second doses of a COVID-19 vaccine. RESULTS: A total of 22 studies with 6522 subjects met the inclusion criteria. After the first vaccine dose, seroconversion in PLWH was comparable to that in healthy individuals. After a second dose, seroconversion was slightly lower in PLWH compared with healthy controls, and antibody titers did not seem to be significantly affected or reduced among participants of both groups. CONCLUSION: COVID-19 vaccines show favorable immunogenicity and efficacy in PLWH. A second dose is associated with consistently improved seroconversion, although it is slightly lower in PLWH than in healthy individuals. Additional strategies, such as a booster vaccination with messenger RNA COVID-19 vaccines, might improve seroprotection for these patients.
Subject(s)
COVID-19 , HIV Infections , Humans , COVID-19 Vaccines , COVID-19/prevention & control , SARS-CoV-2 , Seroconversion , Antibodies, Viral , VaccinationABSTRACT
Objective Available data show that COVID-19 vaccines may be less effective in people living with HIV (PLWH), who are at increased risk of severe COVID-19. This meta-analysis aimed to compare immunogenicity and efficacy of COVID-19 vaccines in PLWH with healthy individuals. Methods Pubmed/Medline, EMBASE, and the Cochrane Library were searched. Risk ratios of seroconversion were separately pooled with the use of random effects meta-analysis, and systematic review without meta-analysis of SARS-CoV-2 antibody titer levels was performed after the first and second doses of a COVID-19 vaccine. Results Twenty-two studies with 6522 subjects met the inclusion criteria. After first vaccine dose, seroconversion in PLWH was comparable to that in healthy individuals. After a second dose, seroconversion was slightly lower in PLWH compared with healthy controls, and antibody titers did not seem to be significantly affected or reduced among participants of both groups. Conclusions COVID-19 vaccines show favorable immunogenicity and efficacy in PLWH. A second dose is associated with consistently improved seroconversion, although it is slightly lower in PLWH compared with healthy individuals. Additional strategies, such as a booster vaccination with mRNA COVID-19 vaccines, might improve seroprotection for these patients.
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Patients with solid cancer have an increased risk of severe coronavirus disease 2019 (COVID-19) and associated mortality than the general population. This meta-analysis aimed to investigate the currently available evidence about the efficacy of COVID-19 vaccines in patients with solid cancer. We included prospective studies comparing the immunogenicity and efficacy of COVID-19 vaccines between patients with solid cancer and healthy individuals. Relative risks of seroconversion after the first and second dose of a COVID-19 vaccine were separately pooled with the use of random effects meta-analysis. Thirty studies with 11,245 subjects met the inclusion criteria. After first vaccine dose, the pooled RR of seroconversion in patients with solid cancer vs healthy individuals was 0.54 (95% CI 0.38-0.78, I2 = 94%). After a second dose, the pooled RR of seroconversion in patients with solid cancer vs healthy controls was 0.87 (0.86-0.88, I2 = 87%). Our review suggests that, compared with healthy individuals, COVID-19 vaccines show favorable immunogenicity and efficacy in patients with solid cancer. A second dose is associated with significantly improved seroconversion, although it is slightly lower in patients with solid cancer compared with healthy individuals.
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The new coronary pneumonia epidemic has had a tremendous impact on the world economic situation, causing a large number of enterprises to suffer from serious losses, but also bringing a large number of entrepreneurial opportunities. For college students, whether the opportunities brought by the epidemic can attract them to step into the entrepreneurial path becomes a question worthy of attention in the process of restoring economic vitality and guiding students' employment and entrepreneurship. In this article, a mediation model was constructed and tested through 245 questionnaire data by combining event system theory, regulatory focus theory, and emotion cognitive evaluation theory. The results showed that defensive regulatory focus and fear of failure and facilitative regulatory focus and fear of failure were all able to continuously mediate the effect of event intensity of the new coronary pneumonia epidemic on the entrepreneurial intentions of college students.
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The novel coronavirus (COVID-19) has become a pandemic and the risk perception plays an important role in self-protection and spread prevention. This study attempts to explore the intrinsic characteristic of risk perception and the spatial distribution of it, which have not been involved in previous studies. To attach this purpose, data from questionnaire conducted in China and Korea (samples of 897 respondents in China and 340 respondents in South Korea) are used to produce risk perception of COVID- 19. Results reveal four principal findings: (1) risk perception of COVID-19 can be categorized into perceived social risk and perceived risk of being infected; (2) the internal differences are most pronounced in perceived risk of being infected about oneself in China, and in perceived social risk disorder about local community in South Korea; (3) the spatial distribution of risk perception is not consistent with that of epidemic severity, for high-risk perception spread out beyond the epicenter with different performance in the two categories; and (4) among the influence factors, trust in information, familiarity with epidemic situation, and interpersonal distance from suffers in the epicenter are found to have a significant influence on different aspects of risk perception. The theoretical and practical implications of this study enrich the understanding of risk perception of epidemic, and provide specific suggestions for preventing this ongoing epidemic spread across the population.